Andrew Mendiola, PhD, is an Assistant Professor in the Department of Pharmacology at the University of California San Diego. He has experience in disease-focused neuroimmunology and neurovascular biology, transcriptional regulation, genomics, and bioinformatics. Andrew’s research focuses on investigating triggers and epigenetic mechanisms governing brain innate immune cell dysfunction, with the goal to develop novel cell- and function-specific therapies for neurologic diseases. His laboratory integrates systems neuroimmunology, multiomics with computational biology, mouse models and tissue culture, functional genomics with CRISPR, immune profiling and sorting via flow cytometry, histopathology, and biochemistry techniques, as a multifaceted experimental approach to address the biological complexity of microglial functions in neurologic diseases such as multiple sclerosis and Alzheimer’s disease.

Prior to joining UCSD, Andrew received his PhD in cellular and molecular biology from the University of Texas at San Antonio. He then went on to complete a NMSS- and NIH-funded postdoctoral fellowship at the Gladstone Institutes, University of California San Francisco.

Andrew received many honors & awards for his research and scholarship including a NIH Pathway to Independence Award (MOSAIC K99/R00), a National Multiple Sclerosis Society Postdoctoral Fellowship, and a 2020 Dorman Prize for best postdoc publication at Gladstone Institutes.





Research Interests:

Microglia, innate immunity, neuroinflammation, neurodegeneration, gene regulation, BBB disruption, fibrinogen, mitochondria, oxidative stress, multiple sclerosis, Alzheimer’s disease, single-cell analyses
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Contact

asmendiola@health.ucsd.edu

Mailing Address:
UC San Diego
Dr. Andrew S. Mendiola
Assistant Professor
9500 Gilman Drive, BSB 3036
La Jolla, CA 92093


Research Funding


2021-2023

NIH Pathway to Independence Award, MOSAIC K99/R00

Agency: NIH, NINDS
Role: Principal Investigator
Title: Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation
Grant#: K99 NS126707
Award: $241,728 (K99 phase, $223,822 Direct Costs)

2020-2021

Berkelhammer Award for Excellence in Neuroscience

Agency: Gladstone Institute of Neurological Disease
Role: Awardee
Award: $25,000

2018-2021

Postdoctoral Fellowship

Agency: National Multiple Sclerosis Society
Title: In vivo imaging and profiling of mechanisms of T-cell recruitment and activation during neuroinflammation
Role: Principal Investigator
Grant #: FG-1708-28925
Award: $177,243

2017-2018

UCSF ImmunoX T32 Postdoctoral Fellowship

Agency: NIH, NIAID
Title: Functional profiling of ligand-selective activation of complement receptor 3 in macrophages
Role: Trainee
Grant #: AI007334
Award: $47,484

2013-2017

Research Training Initiative for Student Enhancement (RISE) Predoctoral Fellowship

Agency: NIH, NIGMS; G-RISE UTSA Program
Role: Trainee Award: $25,000/year

Honors and Awards


2022-2027
Pathway to Independence Award, NIH/NINDS MOSAIC K99/R00
2022
Career Transition Award, National Multiple Sclerosis Society (declined due to overlap with K99)
2021
Robert and Linda Mahley Career Advancement Award, Gladstone Institutes
2021
Dorman Outstanding Postdoctoral Paper Prize (voted by faculty), Gladstone Institutes
2021
Science Advisor, National Multiple Sclerosis Society Emerging Leaders Board
2020
NMSS Postdoc Fellowship: external sponsorship by the Research Rough Riders,Kansas City NS Bike Team
2020
Berkelhammer Award for Excellence in Neuroscience, Gladstone Institutes
2020
Distinguished Achievement in Science Award for Neurological Disease, Gladstone Institutes
2019
Best Poster Presentation, Gladstone Institutes Scientific Retreat
2019
Oral Presentation Award, Aegean Conferences 16th International Conference on Innate Immunity
2019
Invited Speaker, NMSS Leadership Conference
2018-2021
Postdoctoral Fellowship, National Multiple Sclerosis Society
2017-2018
Postdoctoral Fellowship, NIH/NIAID UCSF Immunology T32
2017
Who’s Who Among Students in American Universities and Colleges
2017
ASNeuro Travel Award, American Society of Neurochemistry
2016-2017
Presidential Dissertation Fellowship, UTSA
2016
Poster Award, American Association for Immunologist
2016
Best Poster Award, SALSI Neuroscience Symposium
2016
Best Oral Presentation, UTSA College of Science Conference
2015
Travel Award, Research in Vision and Ophthalmology
2015
Best Oral Presentation, UTSA College of Science Conference
2013-2017
Predoctoral Fellowship, NIH/NIGMS RISE UTSA Program