1. Mendiola AS and Akassoglou K. Fibrin induces neurotoxic microglia gene programs in neurodegeneration. Nat Immunol (2023).

2. Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora M, Zamvil S, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol (2023). [PubMed Link]

3. Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff R, Kaur T, Cardona AE. Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not CX3CR1-KO or hCX3CR1I249/M280-expressing retina. Front Immunol (2023). [PubMed Link]

4. Mendiola AS*‡, Church KA*, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem (2022) [PubMed Link] *co-first authorship, ‡co-corresponding author, Article selected for Issue Cover Image

5. Borna S, Cardona SM, Church KA, Vanegas D, Velazquez P, Rorex C, Rodriguez D, Mendiola AS, Kern TS, Domingo ND, Stephens R, Muzzio IA, Cardona AE. Defibrinogenation ameliorates retinal microgliosis and inflammation in a CX3CR1-independent manner. ASN Neuro (2022); 14:17590914221131446 [PubMed Link]

6. Mendiola AS*, Tognatta R*, Yan Z, Akassoglou K. ApoE and immunity in Alzheimer’s disease and related tauopathies: Low-density lipoprotein receptor to the rescue. Neuron, 15, 2363-2365 (2021) [PubMed Link] *co-first authorship

7. Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevado R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K. BMP receptor blockade overcomes extrinsic inhibition of remyeliaton and restores neurovascular homeostasis. Brain, 8, 2291-2301 (2021) [PubMed Link] Article selected for Issue Cover Image

8. Chan J, Merlini M, Mendiola AS, Akassoglou K, Rubenstein J, Ryu JK. Blood coagulation factor fibrinogen in tumor pathogenesis of central nervous system B-cell lymphoma. Am J Pathol, 191, 575-583 (2021) [PubMed Link]

9. Merlini M, Rafalski V, Ma K, Rios Coronado PE, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Meza-Acevedo R, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci, 24, 19-23 (2021) [PubMed Link]

10. Mendiola AS*, Ryu JK*, Bardehle S, Meyer-Franke A, Ang KKH, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalksi VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Macado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol, 21, 513-524 (2020) [PubMed Link] *co-first authorship, News & Views

11. Willis C, Nicaise A, Menoret A, Ryu JK, Mendiola AS, Jellison E, Givorgri M, Han D, Bongarzone E, Akassoglou K, Vella A, Crocker SJ. Extracellular Vesicle Fibrinogen Induces Encephalitogenic CD8+ T cells in a Mouse Model of Multiple Sclerosis. Proc Natl Acad Sci U S A. 116, 10488-10493 (2019) [PubMed Link]

12. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda, SB, Rios Coronado PE, Pedersen LO, Menon V, Baeten KM, Sikorski SL, Bedard C, Bardhele S, Mendiola AS, Davalos D, Macado MR, Hanspers K, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol 19, 1212-1223 (2018) [PubMed Link] News & Views

13. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich S, Parker J, Ospina A, Araque P, Ransohoff RM, Cardona AE. Role of the fractalkine receptor in CNS autoimmune inflammation: New approach utilizing a mouse model expressing the human CX3CR1I249/M280 variant. Front Cell Neurosci 17, 12-365 (2018) [PubMed Link]

14. Mendiola AS, Cardona AE. The IL-1 phenomena in neuroinflammatory diseases. J Neural Transm. 125, 781-795 (2018) [PubMed Link]

15. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron 96, 1003-1012.e7 (2017) [PubMed Link] News & Views

16. Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE. Fractalkine signaling attenuates perivascular clustering of microglia and fibrinogen leakage during systemic inflammation in mouse models of diabetic retinopathy. Front Cell Neurosci 10,10:303 (2017) [PubMed Link]

17. Betts-Obregon BS, Mondragon AA, Mendiola AS, LeBaron RG, Asmis R, Zou T, Gonzalez-Fernandez F, Tsin AT. TGF induces BIGH3 expression and human retinal pericyte apoptosis: a novel pathway of diabetic retinopathy. Eye 30, 1639-1647 (2016) [PubMed Link]

18. Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL Jr. Antifungal activity of Plasmacytoid dendritic cells against Cryptococcus neoformans in vitro requires expression of Dectin-3 (CLEC4D) and reactive oxygen species. Infect Immun 84, 2493-504 (2016) [PubMed Link]

19. Cardona SM*, Mendiola AS*, Yang YC, Adkins SL, Torres V, Cardona AE. Disruption of fractalkine signaling leads to microglial activation and neuronal damage in the diabetic retina. ASN Neuro 7, 5 (2015) [PubMed Link] *co-first authorship

20. Grigsby JG, Cardona SM, Pouw CE, Muniz A, Mendiola AS, Tsin AT, Allen DM, Cardona AE. The role of microglia in diabetic retinopathy. J Ophthalmol 2014, 705783 (2014) [PubMed Link]